If you use email blasts as part of your marketing mix, emarketer has posted an useful overview of average email open and click through rates. The authors note that smaller, more targeted lists tend to work better than big, broad lists.
If your results are below average, you may want to rent a list from the Hanley Wood Multifamily Group. The names are updated regularly, must conform to specific criteria and are able to be filtered by any number of variables.